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Article

Sleep quality varies as a function of 5-HTTLPR genotype and stress.

Psychosomatic medicine - 1 Jan 2000

Brummett Beverly H, Krystal Andrew D, Ashley-Koch Allison, Kuhn Cynthia M, Züchner Stephan, Siegler Ilene C, Barefoot John C, Ballard Edna L, Gwyther Lisa P, Williams Redford B

Abstract excerpt

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele)...

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Identifiers

PMID: 17766685
DOI: 10.1097/PSY.0b013e31814b8de6
PMCID: PMC2758820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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