Article
Sleep quality in a family with hereditary parkinsonism (PARK6).
Sleep medicine - 1 Aug 2008
Tuin I, Voss U, Kessler K, Krakow K, Hilker R, Morales B, Steinmetz H, Auburger G
Abstract excerpt
OBJECTIVES: The autosomal recessive disorder PARK6 manifests as early-onset Parkinson's disease (PD) with a particularly mild progression. PARK6 is of particular scientific interest, since it is caused by loss-of-function mutations in the mitochondrial protein kinase PINK1 and may thus serve as a model for oxidative damage in PD and in other basal ganglia disorders. Sleep disturbances are very common in PD but...
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