Article
CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians.
Mechanisms of ageing and development - 1 Oct 2007
Hurme M, Kivimäki M, Pertovaara M, Lehtimäki T, Karhunen P J, Jylhä M, Hervonen A, Eklund C
Abstract excerpt
Chronic low-grade inflammation is involved in the pathogenesis of many disease conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP). Here we show that the CRP concentration in old people (nonagenarians) is, at least partially, genetically determined, and that the high producer genotype is associated with a shorter life expectancy during follow-up....
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