Article
Study of the association of -667 aquaporin-2 (AQP-2) A/G promoter polymorphism with the incidence and clinical course of chronic kidney disease in Korea.
Renal failure - 1 Jan 2007
Kang Sun Woo, Kim Yang Wook, Kim Yeong Hoon, Sohn Hae Sook, Joo Hyun, Kim Euiyong
Abstract excerpt
BACKGROUND: Impaired urinary concentration is uniformly present with advanced disease in chronic renal failure. Aquaporin-2 (AQP-2) is known to be expressed in the renal collecting duct cells and participates in urinary concentration in response to vasopressin. Recently, the study of AQP expression in various forms of chronic kidney disease (CKD) demonstrated a reduction in AQP-2 expression associated with a loss...
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