Potassium channels lost during harvesting of epithelial cells are restored with a kinetics that depends on channel species.

Abstract excerpt

The polarized distribution of K(+) channels in MDCK cells is lost upon harvesting and restored upon re-seeding. Using semi-quantitative PCR, in the present work we find that (i) Cells do not "wait" for the normal recycling of membrane proteins to restore their lost channels, but trigger their replacement, suggesting that the membrane has a way of engaging the nucleus. (ii) Replacement channels do not come from an...

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