Article
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.
Human molecular genetics - 1 Dec 2007
Miyashita Akinori, Arai Hiroyuki, Asada Takashi, Imagawa Masaki, Matsubara Etsuro, Shoji Mikio, Higuchi Susumu, Urakami Katsuya, Kakita Akiyoshi, Takahashi Hitoshi, Toyabe Shinichi, Akazawa Kohei, Kanazawa Ichiro, Ihara Yasuo, Kuwano Ryozo
Abstract excerpt
Alzheimer's disease (AD), the most common form of dementia in the elderly, was found to exhibit a trend toward a higher risk in females than in males through epidemiological studies. Therefore, we hypothesized that gender-related genetic risks could exist. To reveal the ones for late-onset AD (LOAD), we extended our previous genetic work on chromosome 10q (genomic region, 60-107 Mb), and single nucleotide...
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