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Article

NF-kappaB and inflammation in genetic disease.

Biochemical pharmacology - 30 Oct 2006

Sebban Hélène, Courtois Gilles

Abstract excerpt

By responding to pro-inflammatory cytokines, such as IL-1beta and TNF-alpha, and controlling itself the expression of numerous mediators of inflammation, NF-kappaB plays a pivotal role in controlling the proper sequence of events characterizing the inflammation process. Although excessive NF-kappaB activation is often associated with inflammatory signs in many different tissues, impaired NF-kappaB activation can...

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Identifiers

PMID: 16965764
DOI: 10.1016/j.bcp.2006.08.006

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TNF

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