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Article

Efficacy assessment of SNP sets for genome-wide disease association studies.

Nucleic acids research - 1 Jan 2007

Wollstein Andreas, Herrmann Alexander, Wittig Michael, Nothnagel Michael, Franke Andre, Nürnberg Peter, Schreiber Stefan, Krawczak Michael, Hampe Jochen

Abstract excerpt

The power of a genome-wide disease association study depends critically upon the properties of the marker set used, particularly the number and physical spacing of markers, and the level of inter-marker association due to linkage disequilibrium. Extending our previously devised theoretical framework for the entropy-based selection of genetic markers, we have developed a local measure of the efficacy of a marker...

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Identifiers

PMID: 17726055
DOI: 10.1093/nar/gkm621
PMCID: PMC2034459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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