Article
BRAF in papillary thyroid carcinoma of ovary (struma ovarii).
The American journal of surgical pathology - 1 Sept 2007
Schmidt Jason, Derr Victoria, Heinrich Michael C, Crum Christopher P, Fletcher Jonathan A, Corless Christopher L, Nosé Vânia
Abstract excerpt
BACKGROUND: Malignant struma ovarii (MSO) are rare tumors that arise from ectopic thyroid tissue in the ovary, benign struma ovarii (BSO). Most MSO are histologically classified as papillary thyroid carcinomas (PTC). Oncogenic activation of BRAF (35% to 69%), RAS (10%), or RET (5% to 30%) is common in PTC, and the mutations correlate with tumor subtype, patient age, and clinical behavior. In this study, we...
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