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Malignant struma ovarii: Advances in molecular pathogenesis, classification, diagnosis and treatment.

Histopathology - 1 Jul 2026

Lin Wanrun, Zhou Xin, Wang Yudong, Zhou Feng

Abstract excerpt

Malignant struma ovarii (MSO) is an extremely rare ovarian teratoma containing malignant thyroid tissue, typically presenting in middle-aged women. Molecularly and histologically, MSO mirrors thyroid carcinoma and includes analogous subtypes as defined in the 2022 WHO classification: 'BRAF-like' tumours (commonly driven by BRAF^V600E mutations or kinase fusions) and 'RAS-like' tumours (driven by mutations in the...

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Identifiers

PMID: 41684192
DOI: 10.1111/his.70119

Genes

BRAF
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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