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Role of gene sequencing in classifying struma ovarii: BRAF p.G469A mutation and TERT promoter alterations favour malignant struma ovarii.

Histopathology - 1 Jan 2024

Neyrand Sophie, Trecourt Alexis, Lopez Jonathan, Just Pierre Alexandre, Descotes Françoise, Borson-Chazot Françoise, Ray-Coquard Isabelle, Decaussin-Petrucci Myriam, Devouassoux-Shisheboran Mojgan

Abstract excerpt

AIMS: Struma ovarii (SO) are rare, accounting for 0.3-1% of ovarian tumours, and include benign and malignant lesions. In most cases, histology is not predictive of clinical outcome and prognosis. The prognosis of histologically malignant thyroid-type carcinomas can indeed be excellent, while SO, composed of normal thyroid tissue, can recur and are designated highly differentiated follicular carcinoma of the...

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PMID: 37771077
DOI: 10.1111/his.15052

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