Article
Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.
Stroke - 1 Oct 2007
Kölsch Heike, Larionov Sergey, Dedeck Oliver, Orantes Mario, Birkenmeier Gerd, Griffin W Sue T, Thal Dietmar Rudolf
Abstract excerpt
BACKGROUND AND PURPOSE: Glutathione S-transferase omega-1 is a multifunctional enzyme. The Asp/Asp genotype of the Ala140Asp polymorphism of the GSTO1 gene has been alleged to increase the risk of vascular dementia. The objective of this study is to address the question of whether common vessel disorders known to cause vascular dementia are modified in their severity by this polymorphism. METHODS: The severity...
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