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Recombinant adeno-associated virus vectors induce functionally impaired transgene product–specific CD8+ T cells in mice

15 Nov 2007

Abstract excerpt

Recombinant adeno-associated virus (rAAV) vectors were used in human trials as carriers of vaccines for HIV-1 after encouraging preclinical results. However, the clinical trials yielded disappointing results. Here we demonstrated that in mice, rAAV vectors expressing the gene encoding HIV-1 gag stimulated gag-specific CD8(+) T cells, but these T cells failed to expand after a booster immunization with a...

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PMID: 18008010
DOI: 10.1172/jci33138

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