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Article

Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.

Infection and immunity - 1 Aug 1998

Zhang J R, Norris S J

Abstract excerpt

The Lyme disease agent, Borrelia burgdorferi, is able to persistently infect humans and animals for months or years in the presence of an active immune response. It is not known how the organisms survive immune attack in the mammalian host. vlsE, a gene localized near one end of linear plasmid lp28-1 and encoding a surface-exposed lipoprotein in B. burgdorferi B31, was shown recently to undergo extensive genetic...

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Identifiers

PMID: 9673250
DOI: 10.1128/IAI.66.8.3689-3697.1998
PMCID: PMC108403

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Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.PMID 9673250Read ↗

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The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensSemantic proximity Read ↗

Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.Semantic proximity Read ↗

Evidence for the contribution of point mutations to vlsE variation and for apparent constraints on the net accumulation of sequence changes in vlsE during infection with Lyme disease spirochetes.Semantic proximity Read ↗

Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.Semantic proximity Read ↗

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.Semantic proximity Read ↗

Changes in Temporal and Spatial Patterns of Outer Surface Lipoprotein Expression Generate Population Heterogeneity and Antigenic Diversity in the Lyme Disease Spirochete, Borrelia burgdorferiSemantic proximity Read ↗

Evidence That the Variable Regions of the Central Domain of VlsE Are Antigenic during Infection with Lyme Disease SpirochetesSemantic proximity Read ↗

Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1.Semantic proximity Read ↗

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