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Article

Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity - a [11C]DASB PET study.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2007

Reimold M, Smolka M N, Zimmer A, Batra A, Knobel A, Solbach C, Mundt A, Smoltczyk H U, Goldman D, Mann K, Reischl G, Machulla H-J, Bares R, Heinz A

Abstract excerpt

Reduced availability of brainstem serotonin transporters (5-HTT) has been observed in vivo in obsessive-compulsive disorder (OCD). However, results vary and may be influenced by competition with endogenous serotonin. Using positron emission tomography (PET) and [11C]DASB, a specific 5-HTT ligand that showed no competition with serotonin for 5-HTT binding in vitro, we tested the hypothesis that 5-HTT availability...

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PMID: 17713719
DOI: 10.1007/s00702-007-0785-6

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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