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Identification of sensory dysfunction and nervous structure changes in Fam134b knockout mice.

Neurological research - 1 Jan 2023

Chen Binghao, Hu Xingyun, Chen Meiling, Chen Yuying, Yan Li, Zeng Gang, Wang Chuan, Liu Lixuan, Yang Chuan, Song Weidong

Abstract excerpt

OBJECTIVES: Mutation in human FAM134B gene has been implicated in hereditary sensory and autonomic neuropathy type IIB. We aimed to knock out Fam134b in mice and explored its phenotypes to determine whether the genetic impairments and behavioral changes can mirror manifestations noted in humans. METHODS: We used CRISPR/Cas9 technology to knockout the Fam134b gene in the C57BL/6 J mouse. After confirming the...

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Identifiers

PMID: 36302074
DOI: 10.1080/01616412.2022.2117947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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