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Article

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Blood - 15 Nov 2007

Menzel Stephan, Jiang Jie, Silver Nicholas, Gallagher Joy, Cunningham Juliette, Surdulescu Gabriela, Lathrop Mark, Farrall Martin, Spector Tim D, Thein Swee Lay

Abstract excerpt

Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other...

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Source

Identifiers

PMID: 17712044
DOI: 10.1182/blood-2007-05-093419

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.PMID 17712044Read ↗

A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression.Semantic proximity Read ↗

The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carriers of β-thalassaemiaSemantic proximity Read ↗

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.Semantic proximity Read ↗

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HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers.Semantic proximity Read ↗

The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cellsSemantic proximity Read ↗

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