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A Novel Method to Capture Methylated Human DNA from Stool: Implications for Colorectal Cancer Screening

21 Aug 2007

Abstract excerpt

BACKGROUND: Assay of methylated DNA markers in stool is a promising approach for colorectal cancer (CRC) screening. A method to capture hypermethylated CpG islands from stool would enrich target analyte and allow optimal assay sensitivity. METHODS: Methyl-binding domain (MBD) protein was produced using a pET6HMBD plasmid with MBD DNA sequence cloned from rat MeCP2 gene and bound to a column of nickel-agarose...

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PMID: 17712002
DOI: 10.1373/clinchem.2007.086223

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