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A Simplified, Noninvasive Stool DNA Test for Colorectal Cancer Detection

27 Aug 2008

Abstract excerpt

BACKGROUND: As a noninvasive colorectal cancer (CRC) screening test, a multi-marker first generation stool DNA (sDNA V 1.0) test is superior to guaiac-based fecal occult blood tests. An improved sDNA assay (version 2), utilizing only two markers, hypermethylated vimentin gene (hV) and a two site DNA integrity assay (DY), demonstrated in a training set (phase 1a) an even higher sensitivity (88%) for CRC with a...

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PMID: 18759824
DOI: 10.1111/j.1572-0241.2008.02088.x

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