Article
Transbilayer phospholipid movements in ABCA1-deficient cells.
PloS one - 15 Aug 2007
Williamson Patrick, Halleck Margaret S, Malowitz Jonathan, Ng Susan, Fan Xiaoxuan, Krahling Stephen, Remaley Alan T, Schlegel Robert A
Abstract excerpt
Tangier disease is an inherited disorder that results in a deficiency in circulating levels of HDL. Although the disease is known to be caused by mutations in the ABCA1 gene, the mechanism by which lesions in the ABCA1 ATPase effect this outcome is not known. The inability of ABCA1 knockout mice (ABCA1-/-) to load cholesterol and phospholipids onto apoA1 led to a proposal that ABCA1 mediates the transbilayer...
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