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Article

Transbilayer phospholipid movements in ABCA1-deficient cells.

PloS one - 15 Aug 2007

Williamson Patrick, Halleck Margaret S, Malowitz Jonathan, Ng Susan, Fan Xiaoxuan, Krahling Stephen, Remaley Alan T, Schlegel Robert A

Abstract excerpt

Tangier disease is an inherited disorder that results in a deficiency in circulating levels of HDL. Although the disease is known to be caused by mutations in the ABCA1 gene, the mechanism by which lesions in the ABCA1 ATPase effect this outcome is not known. The inability of ABCA1 knockout mice...

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Share to ATP Binding Cassette Transporter 1
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Share to Lipid Bilayers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17710129
DOI: 10.1371/journal.pone.0000729
PMCID: PMC1939730

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17710129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Transbilayer phospholipid movements in ABCA1-deficient cells.PMID 17710129Read ↗

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ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?Semantic proximity Read ↗

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.Semantic proximity Read ↗

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.Semantic proximity Read ↗

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.Semantic proximity Read ↗

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