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Article

Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.

The Journal of biological chemistry - 30 Mar 2001

Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G

Abstract excerpt

The identification of defects in ABCA1 as the molecular basis of Tangier disease has highlighted its crucial role in the loading with phospholipids and cholesterol of nascent apolipoprotein particles. Indeed the expression of ABCA1 affects apolipoprotein A-I (apoA-I)-mediated removal of lipids from cell membranes, and the possible role of ABCA1 as an apoA-I surface receptor has been recently suggested. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11150301
DOI: 10.1074/jbc.M010265200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter.PMID 11150301Read ↗

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.Semantic proximity Read ↗

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The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.Semantic proximity Read ↗

Carboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cells.Semantic proximity Read ↗

Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.Semantic proximity Read ↗

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.Semantic proximity Read ↗

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.Semantic proximity Read ↗

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein.Semantic proximity Read ↗

Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis.Semantic proximity Read ↗

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.Semantic proximity Read ↗

Endocytosis is enhanced in Tangier fibroblasts: possible role of ATP-binding cassette protein A1 in endosomal vesicular transport.Semantic proximity Read ↗

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