Article
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
Human pathology - 1 Nov 2007
Prall Friedrich, Ostwald Christiane
Abstract excerpt
In vitro ras activation enhances the epithelial-mesenchymal transition of colorectal carcinoma cells. But ras effects are known to be highly dependent on cell types and the tissue context. Therefore, this study was made to test the hypothesis that in clinical colorectal carcinoma specimens, aggressive invasion phenotypes, specifically tumor budding and podia formation, would correlate with K-ras gene mutations....
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