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Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives

1 Aug 2007

Abstract excerpt

Hypotheses on the origin and distribution of extragonadal germ cell tumours (GCTs) and teratomas are briefly reviewed and revisited in the light of (i) new developments in the classification of GCTs, (ii) data on genomic imprinting of these neoplasms and (iii) the recent finding that germ cells can be derived from mouse and human embryonal stem (ES) cells. Only the Type I (infantile teratomas/yolk sac tumours)...

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PMID: 17705807
DOI: 10.1111/j.1365-2605.2007.00793.x

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