Article
New insights into type II germ cell tumor pathogenesis based on studies of patients with various forms of disorders of sex development (DSD).
Molecular and cellular endocrinology - 10 Sept 2008
Hersmus Remko, de Leeuw Bertie H C G M, Wolffenbuttel Katja P, Drop Stenvert L S, Oosterhuis J Wolter, Cools Martine, Looijenga Leendert H J
Abstract excerpt
Disorders of sex development (DSD), previously known as intersex, refer to congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Patients with specific variants of this disorder have an elevated risk for the development of so-called type II germ cell cancers, i.e., the seminomatous and nonseminatous tumors, referred to as germ cell tumors (GCTs). Specifically DSD...
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