Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1 Jun 1997

Abstract excerpt

Interferon (IFN)-gamma increases the sensitivity of tumor cell lines, many of which are p53 mutants, to tumor necrosis factor-alpha-mediated and anti-Fas antibody-mediated cell death. To better understand the mechanism of IFN-gamma action in modulating the cell death response independently of p53 function, we analyzed the death of the human colon adenocarcinoma cell line, HT-29, following treatment with IFN-gamma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9195941
DOI: 10.1074/jbc.272.26.16351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene ExpressionPMID 9195941Read ↗

IFN-gammaupregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma.Semantic proximity Read ↗

Coordinate Regulation of IFN Consensus Sequence-Binding Protein and Caspase-1 in the Sensitization of Human Colon Carcinoma Cells to Fas-Mediated Apoptosis by IFN-γSemantic proximity Read ↗

IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.Semantic proximity Read ↗

Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.Semantic proximity Read ↗

Interferon-γ Sensitizes Human Myeloid Leukemia Cells to Death Receptor-mediated Apoptosis by a Pleiotropic MechanismSemantic proximity Read ↗

The Interferon Stimulated Gene 54 Promotes ApoptosisSemantic proximity Read ↗

Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis.Semantic proximity Read ↗

Signaling through IFN Regulatory Factor-5 Sensitizes p53-Deficient Tumors to DNA Damage–Induced Apoptosis and Cell DeathSemantic proximity Read ↗

IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes.Semantic proximity Read ↗

Alpha-Interferon and Its Effects on Signalling Pathways Within CellsSemantic proximity Read ↗

Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines.Semantic proximity Read ↗

p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.