Article
Transcription of a stem/loop region of a tumour-amplified sequence induces bacterial aggregation.
Journal of general microbiology - 1 Oct 1991
Heighway J, Leverton K E
Abstract excerpt
A sequence of human DNA, amplified in a lung tumour, was shown to induce expression-dependent effects on Escherichia coli phenotype. Previous studies have demonstrated the induction of abnormal plasmid supercoiling and bacterial aggregation in host strains harbouring various constructs encoding this region. Subcloning identified a short stretch of 50 bp crucial for these effects. This study details further...
Topics
- Bacterial Adhesion
- Base Sequence
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Escherichia coli
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutagenesis
- Mutagenesis, Site-Directed
- Nucleic Acid Conformation