Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2D6*4 polymorphism is associated with statin-induced muscle effects.

Pharmacogenetics and genomics - 1 Sept 2007

Frudakis Tony N, Thomas Matthew J, Ginjupalli Siva N, Handelin Barbara, Gabriel Richard, Gomez Hector J

Abstract excerpt

Statin use is associated with a variety of overtly related muscle symptoms including muscle pain, myalgia, creatine kinase elevations without pain with myolysis and myositis (rhabdomyolysis), a potentially fatal side effect that led to the withdrawal of cerivastatin in 2001. Unintended drug response phenotypes have an impact on patient compliance and sometimes patient health and the assessment of risk on an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atorvastatin
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heptanoic Acids

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Muscles

Share to Pharmacogenetics

Share to Pyrroles

Share to Simvastatin

Source

Identifiers

PMID: 17700359
DOI: 10.1097/FPC.0b013e328012d0a9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2D6*4 polymorphism is associated with statin-induced muscle effects.PMID 17700359Read ↗

The Association between Genetic Polymorphisms and Simvastatin-Induced Myopathy: A Narrative Synthesis of Evidence.Semantic proximity Read ↗

Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.Semantic proximity Read ↗

Pharmacogenetics of Statin-Induced Myopathy: A Focused Review of the Clinical Translation of Pharmacokinetic Genetic VariantsSemantic proximity Read ↗

Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence.Semantic proximity Read ↗

Genetic and Clinical Factors Are Associated With Statin-Related Myotoxicity of Moderate Severity: A Case-Control Study.Semantic proximity Read ↗

Approach to clinical and genetic characterization of statin-induced myopathy.Semantic proximity Read ↗

Statin-associated muscle toxicity : clinical and genomic perspectivesSemantic proximity Read ↗

Statin myotoxicity: a review of genetic susceptibility factors.Semantic proximity Read ↗

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle ComponentsSemantic proximity Read ↗

Pharmacogenomic insights into treatment and management of statin-induced myopathySemantic proximity Read ↗

Clinical implications of pharmacogenetic variation on the effects of statins.Semantic proximity Read ↗

The genetics of statin-induced myopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.