Article
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2007
Gumz Michelle L, Zou Hongzhi, Kreinest Pamela A, Childs April C, Belmonte Leandra S, LeGrand Shauna N, Wu Kevin J, Luxon Bruce A, Sinha Mala, Parker Alexander S, Sun L-Z, Ahlquist David A, Wood Christopher G, Copland John A
Abstract excerpt
PURPOSE: Incidence and mortality rates for renal cell carcinoma (RCC) have been rising for decades. Unfortunately, the molecular events that support RCC carcinogenesis remain poorly understood. In an effort to gain a better understanding of signaling events in clear cell RCC (cRCC), we investigated the antitumor activity of secreted frizzled-related protein 1 (sFRP1), a negative regulator of Wnt signaling....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.