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Article

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

1 Dec 2011

Abstract excerpt

BACKGROUND: Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-grade ccRCC must be clarified. In the present study, we found that SAV1 was significantly downregulated with copy number loss in high-grade ccRCCs. Therefore, we investigated the SAV1 function on...

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PMID: 22185343
DOI: 10.1186/1471-2407-11-523

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