Article
Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?
Human mutation - 1 Jan 2008
Anczuków Olga, Ware Mark D, Buisson Monique, Zetoune Almoutassem B, Stoppa-Lyonnet Dominique, Sinilnikova Olga M, Mazoyer Sylvie
Abstract excerpt
The nonsense-mediated mRNA decay (NMD) mechanism is an evolutionarily conserved process ensuring the degradation of transcripts carrying premature termination codon(s). NMD is believed to prevent the synthesis of truncated proteins that could be detrimental to the cell. However, although numerous studies have assessed the efficiency of this mechanism at the mRNA level, data are lacking in regard to whether NMD...
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