Article
A single positively selected West Nile viral mutation confers increased virogenesis in American crows.
Nature genetics - 1 Sept 2007
Brault Aaron C, Huang Claire Y-H, Langevin Stanley A, Kinney Richard M, Bowen Richard A, Ramey Wanichaya N, Panella Nicholas A, Holmes Edward C, Powers Ann M, Miller Barry R
Abstract excerpt
West Nile virus (WNV), first recognized in North America in 1999, has been responsible for the largest arboviral epiornitic and epidemic of human encephalitis in recorded history. Despite the well-described epidemiological patterns of WNV in North America, the basis for the emergence of WNV-associated avian pathology, particularly in the American crow (AMCR) sentinel species, and the large scale of the North...
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