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Article

Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns.

Carcinogenesis - 1 Sept 2007

Lea I A, Jackson M A, Li X, Bailey S, Peddada S D, Dunnick J K

Abstract excerpt

Cancer is a complex disease that involves the accumulation of both genetic and epigenetic alterations of numerous genes. Data in the Genetic Alterations in Cancer database for gene mutations and allelic loss [loss of heterozygosity (LOH)] in human tumors (e.g. lung, oral, esophagus, stomach and colon/rectum) were reviewed. Results for the genes and pathways implicated in tumor development at these sites are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17693665
DOI: 10.1093/carcin/bgm176
PMCID: PMC2131731

Genes

KRAS
APC
BRAF
FHIT
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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