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Article

Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2006

Leone Francesco, Cavalloni Giuliana, Pignochino Ymera, Sarotto Ivana, Ferraris Renato, Piacibello Wanda, Venesio Tiziana, Capussotti Lorenzo, Risio Mauro, Aglietta Massimo

Abstract excerpt

OBJECTIVE: Conventional therapies are still unsuccessful in patients with carcinoma arising from the biliary tract. Somatic mutations of the epidermal growth factor receptor (EGFR) gene and the activation of its downstream pathways predict the sensitivity to small-molecule inhibitors in non-small cell lung carcinoma. Therefore, we analyzed EGFR mutations and related pathways in gallbladder and bile duct...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16551849
DOI: 10.1158/1078-0432.CCR-05-1692

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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