Article
African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine.
AIDS (London, England) - 20 Aug 2007
Kuhn Louise, Schramm Diana B, Donninger Samantha, Meddows-Taylor Stephen, Coovadia Ashraf H, Sherman Gayle G, Gray Glenda E, Tiemessen Caroline T
Abstract excerpt
BACKGROUND: Individuals with more copies of CCL3L1 (CCR5 ligand) than their population median have been found to be less susceptible to HIV infection. We investigated whether maternal or infant CCL3L1 gene copy numbers are associated with perinatal HIV transmission when single-dose nevirapine is given for prevention. METHOD: A nested case-control study was undertaken combining data from four cohorts including 849...
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