Article
Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission.
The Journal of general virology - 1 Jul 2006
Meddows-Taylor Stephen, Donninger Samantha L, Paximadis Maria, Schramm Diana B, Anthony Fiona S, Gray Glenda E, Kuhn Louise, Tiemessen Caroline T
Abstract excerpt
The role of CC chemokines in protection against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission is not well understood. It was observed that mitogen-induced production of CCL3 and CCL4 by cord-blood mononuclear cells was increased among infants born to HIV-positive compared with HIV-negative mothers, and that a deficiency in production of CCL3 was associated with increased susceptibility...
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