Article
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene.
Brain research - 5 Sept 2007
Morimoto Nobutoshi, Nagai Makiko, Ohta Yasuyuki, Miyazaki Kazunori, Kurata Tomoko, Morimoto Mizuki, Murakami Tetsuro, Takehisa Yasushi, Ikeda Yoshio, Kamiya Tatsushi, Abe Koji
Abstract excerpt
Autophagy, like the ubiquitin-proteasome system, is considered to play an important role in preventing the accumulation of abnormal proteins. Rat microtubule-associated protein 1 light chain 3 (LC3) is important for autophagy, and the conversion from LC3-I into LC3-II is accepted as a simple method for monitoring autophagy. We examined a SOD1G93A transgenic mouse model for amyotrophic lateral sclerosis (ALS) to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.