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Article

Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2010

Pratt-Hyatt Matthew, Lin Hsia-lien, Hollenberg Paul F

Abstract excerpt

Although the ability of disulfiram to inactivate CYP2E1 has been known for more than 20 years, the mechanism has not yet been elucidated. A metabolite of disulfiram, diethyldithocarbamate (DDC), is converted by CYP2E1 to a reactive intermediate that subsequently inactivates the protein, leading t...

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Identifiers

PMID: 20826547
DOI: 10.1124/dmd.110.034710
PMCID: PMC2993453

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20826547-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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