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Article

Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities.

Clinical colorectal cancer - 1 Jul 2007

Fakih Marwan G, Ross Mary Ellen, Starostik Petr

Abstract excerpt

BACKGROUND: Uridine diphosphate glucuronosyltransferase (UGT) 1A1 7/7 polymorphism has been linked with an increased risk of irinotecan-induced severe toxicities. We evaluated UGT1A1 polymorphism in patients developing grade 3/4 toxicity after initiation of irinotecan to determine the frequency of this polymorphism in this population. PATIENTS AND METHODS: Twenty patients with grade 3/4 irinotecan-induced...

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Identifiers

PMID: 17681105
DOI: 10.3816/CCC.2007.n.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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