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Article

Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer.

The Prostate - 1 Oct 2007

Daugherty Sarah E, Shugart Yin Yao, Platz Elizabeth A, Fallin M Daniele, Isaacs William B, Pfeiffer Ruth M, Welch Robert, Huang Wen-Yi, Reding Douglas, Hayes Richard B

Abstract excerpt

BACKGROUND: Alpha-methylacyl-CoA racemase (AMACR), which prepares branched chain fatty acids to be metabolized for energy and is implicated in the activation of the COX-inhibiting form of ibuprofen, is overexpressed in prostate cancer and its precursor lesions. Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of...

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Identifiers

PMID: 17680641
DOI: 10.1002/pros.20635

Genes

AMACR

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