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Article

Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.

PloS one - 1 Jan 2012

Azrad Maria, Zhang Kui, Vollmer Robin T, Madden John, Polascik Thomas J, Snyder Denise C, Ruffin Mack T, Moul Judd W, Brenner Dean, Hardy Robert W, Demark-Wahnefried Wendy

Abstract excerpt

Previous observational studies have reported associations between prostate cancer and alpha-linolenic acid (ALA). However, few investigations have been able to study this relationship prospectively and in well-controlled settings. Moreover, no studies have determined whether single nucleotide polymorphisms (SNPs) that influence ALA metabolism are associated with this common cancer. The purpose of this study was...

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PMID: 23285256
DOI: 10.1371/journal.pone.0053104
PMCID: PMC3532426

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