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Article

Tempo and mode in the endocannaboinoid system.

Journal of molecular evolution - 1 Sept 2007

McPartland John M, Norris Ryan W, Kilpatrick C William

Abstract excerpt

The best-known endocannabinoid ligands, anandamide and 2-AG, signal at least seven receptors and involve ten metabolic enzymes. Genes for the receptors and enzymes were examined for heterogeneities in tempo (relative rate of evolution, RRE) and mode (selection pressure, Ka/Ks) in six organisms with sequenced genomes. BLAST identified orthologs as reciprocal best hits, and nucleotide alignments were performed with...

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Source

Identifiers

PMID: 17676365
DOI: 10.1007/s00239-007-9004-1

Genes

GPR55
PTPN22
TRPV1
FAAH2
NAAA
TRPA1
TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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