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Article

The dynamic epigenome and its implications in toxicology.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2007

Szyf Moshe

Abstract excerpt

The epigenome serves as an interface between the dynamic environment and the inherited static genome. The epigenome is comprised of chromatin and a covalent modification of DNA by methylation. The epigenome is sculpted during development to shape the diversity of gene expression programs in the different cell types of the organism by a highly organized process. Epigenetic aberrations have similar consequences to...

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Identifiers

PMID: 17675334
DOI: 10.1093/toxsci/kfm177

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