Article
The social environment and the epigenome.
Environmental and molecular mutagenesis - 1 Jan 2008
Szyf Moshe, McGowan Patrick, Meaney Michael J
Abstract excerpt
The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in somatic tissues. Recent data suggest that DNA methylation is dynamic later in life in postmitotic...
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