Article
Epigenetic gene regulation: linking early developmental environment to adult disease.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2000
Dolinoy Dana C, Weidman Jennifer R, Jirtle Randy L
Abstract excerpt
Traditional studies on the combined effects of genetics and the environment on individual variation in disease susceptibility primarily focus on single nucleotide polymorphisms that influence toxicant uptake and metabolism. A growing body of evidence, however, suggests that epigenetic mechanisms of gene regulation, such as DNA methylation and chromatin modification, are also influenced by the environment, and...
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