Article
Genome scan implicates adhesion biological pathways in secondary leukemia.
Leukemia - 1 Oct 2007
Hartford C, Yang W, Cheng C, Fan Y, Liu W, Treviño L, Pounds S, Neale G, Raimondi S C, Bogni A, Dolan M E, Pui C-H, Relling M V
Abstract excerpt
The genetic risk factors for etoposide-induced leukemia with MLL translocations remain largely unknown. To identify genetic risk factors for and novel characteristics of secondary leukemia, we profiled 116,204 single nucleotide polymorphisms (SNPs) in germline and paired leukemic cell DNA from 13 secondary leukemia/myelodysplasia cases and germline DNA from 13 matched and 156 unmatched controls, all with acute...
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