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Article

Discovery of the Philadelphia chromosome: a personal perspective

1 Aug 2007

Abstract excerpt

Almost 50 years ago, David Hungerford and I noticed an abnormally small chromosome in cells from patients with chronic myelogenous leukemia (CML). This article is a personal perspective of the events leading to the discovery of this chromosome, which became known as the Philadelphia chromosome. As technology advanced over subsequent decades, the translocation resulting in the Philadelphia chromosome has been...

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Identifiers

PMID: 17671636
DOI: 10.1172/jci31771

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Related research

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Research trail→

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Discovery of the Philadelphia chromosome: a personal perspectivePMID 17671636Read ↗

The legacy of the Philadelphia chromosomeSemantic proximity Read ↗

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Translation of the Philadelphia chromosome into therapy for CMLSemantic proximity Read ↗

Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenetic and prognostic implicationsSemantic proximity Read ↗

The parental origin of the Philadelphia chromosome: evidence of additional, recurring recombinatorial events.Semantic proximity Read ↗

Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesisSemantic proximity Read ↗

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Lozzio CB, Lozzio BB. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood. 1975;45(3):321-334.Semantic proximity Read ↗

Current Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

A variant Philadelphia chromosome (Ph1) positive chronic myelocytic leukemia.Semantic proximity Read ↗

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