Article
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
Molecular psychiatry - 1 Dec 2007
Francks C, Maegawa S, Laurén J, Abrahams B S, Velayos-Baeza A, Medland S E, Colella S, Groszer M, McAuley E Z, Caffrey T M, Timmusk T, Pruunsild P, Koppel I, Lind P A, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson A J, Riley B P, Martin N G, Strittmatter S M, Möller H-J, Rujescu D, St Clair D, Muglia P, Roos J L, Fisher S E, Wade-Martins R, Rouleau G A, Stein J F, Karayiorgou M, Geschwind D H, Ragoussis J, Kendler K S, Airaksinen M S, Oshimura M, DeLisi L E, Monaco A P
Abstract excerpt
Left-right asymmetrical brain function underlies much of human cognition, behavior and emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders. The molecular, developmental and evolutionary origins of human brain asymmetry are unknown. We found significant association of a haplotype upstream of the gene LRRTM1 (Leucine-rich repeat transmembrane neuronal...
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