Article
Genome-wide association study identifies 48 common genetic variants associated with handedness.
Nature human behaviour - 1 Jan 2021
Cuellar-Partida Gabriel, Tung Joyce Y, Eriksson Nicholas, Albrecht Eva, Aliev Fazil, Andreassen Ole A, Barroso Inês, Beckmann Jacques S, Boks Marco P, Boomsma Dorret I, Boyd Heather A, Breteler Monique M B, Campbell Harry, Chasman Daniel I, Cherkas Lynn F, Davies Gail, de Geus Eco J C, Deary Ian J, Deloukas Panos, Dick Danielle M, Duffy David L, Eriksson Johan G, Esko Tõnu, Feenstra Bjarke, Geller Frank, Gieger Christian, Giegling Ina, Gordon Scott D, Han Jiali, Hansen Thomas F, Hartmann Annette M, Hayward Caroline, Heikkilä Kauko, Hicks Andrew A, Hirschhorn Joel N, Hottenga Jouke-Jan, Huffman Jennifer E, Hwang Liang-Dar, Ikram M Arfan, Kaprio Jaakko, Kemp John P, Khaw Kay-Tee, Klopp Norman, Konte Bettina, Kutalik Zoltan, Lahti Jari, Li Xin, Loos Ruth J F, Luciano Michelle, Magnusson Sigurdur H, Mangino Massimo, Marques-Vidal Pedro, Martin Nicholas G, McArdle Wendy L, McCarthy Mark I, Medina-Gomez Carolina, Melbye Mads, Melville Scott A, Metspalu Andres, Milani Lili, Mooser Vincent, Nelis Mari, Nyholt Dale R, O'Connell Kevin S, Ophoff Roel A, Palmer Cameron, Palotie Aarno, Palviainen Teemu, Pare Guillaume, Paternoster Lavinia, Peltonen Leena, Penninx Brenda W J H, Polasek Ozren, Pramstaller Peter P, Prokopenko Inga, Raikkonen Katri, Ripatti Samuli, Rivadeneira Fernando, Rudan Igor, Rujescu Dan, Smit Johannes H, Smith George Davey, Smoller Jordan W, Soranzo Nicole, Spector Tim D, Pourcain Beate St, Starr John M, Stefánsson Hreinn, Steinberg Stacy, Teder-Laving Maris, Thorleifsson Gudmar, Stefánsson Kári, Timpson Nicholas J, Uitterlinden André G, van Duijn Cornelia M, van Rooij Frank J A, Vink Jaqueline M, Vollenweider Peter, Vuoksimaa Eero, Waeber Gérard, Wareham Nicholas J, Warrington Nicole, Waterworth Dawn, Werge Thomas, Wichmann H-Erich, Widen Elisabeth, Willemsen Gonneke, Wright Alan F, Wright Margaret J, Xu Mousheng, Zhao Jing Hua, Kraft Peter, Hinds David A, Lindgren Cecilia M, Mägi Reedik, Neale Benjamin M, Evans David M, Medland Sarah E
Abstract excerpt
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated...