Article
Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia.
European journal of clinical pharmacology - 1 Oct 2007
Doki Kosuke, Homma Masato, Kuga Keisuke, Aonuma Kazutaka, Sakai Satoshi, Yamaguchi Iwao, Kohda Yukinao
Abstract excerpt
OBJECTIVE: We examined the effect of gender-associated differences in pharmacokinetics on the anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia and in healthy subjects. METHODS: The study population comprised 72 outpatients (52 males and 20 females) treated with oral flecainide for supraventricular tachyarrhythmias. Serum flecainide concentrations were determined by...
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