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Article

Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis†

20 Jul 2007

Abstract excerpt

UNLABELLED: Recent work has demonstrated enhanced X monosomy in women with primary biliary cirrhosis (PBC) as well as two other female-predominant autoimmune diseases, systemic sclerosis and autoimmune thyroid disease. To further our understanding of these events, we have investigated the mechanisms of X chromosome loss and X chromosome inactivation (XCI) in 166 women with PBC and 226 rigorously age-matched...

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Identifiers

PMID: 17659578
DOI: 10.1002/hep.21696

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